Biochem/physiol Actions
Cell permeable: no
Reversible: no
Primary TargetNegative control for Shh (Sonic Hedgehog) signaling
Product does not compete with ATP.
General description
A steroidal alkaloid that structurally resembles Cyclopamine (Cat. No. 239803), but lacks the capacity to inhibit Sonic Hedgehog (Shh) signaling. Reported to be non-teratogenic. Useful as a negative control.
A steroidal alkaloid that structurally resembles Cyclopamine (Cat. No. 239803), but lacks the capacity to inhibit Shh (Sonic Hedgehog) signaling. Reported to be non-teratogenic.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Berman, D.M., et al. 2003. Nature,425, 846.Thayer, S.P., et al. 2003. Nature,425, 851.Watkins, D.N., et al. 2003. Nature422, 313.Cooper, M.K., et al. 1998. Science280, 1603.Kim, S.K. and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA95, 13036.
Packaging
Packaged under inert gas
25 mg in Plastic ampoule
Preparation Note
Slight warming may be required to achieve complete solubilization.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Warning
Toxicity: Standard Handling (A)
This product has met the following criteria to qualify for the following awards: