Biochem/physiol Actions

Cell permeable: no

Reversible: no

Primary TargetNegative control for Shh (Sonic Hedgehog) signaling

Product does not compete with ATP.

General description

A steroidal alkaloid that structurally resembles Cyclopamine (Cat. No. 239803), but lacks the capacity to inhibit Sonic Hedgehog (Shh) signaling. Reported to be non-teratogenic. Useful as a negative control.

A steroidal alkaloid that structurally resembles Cyclopamine (Cat. No. 239803), but lacks the capacity to inhibit Shh (Sonic Hedgehog) signaling. Reported to be non-teratogenic.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Berman, D.M., et al. 2003. Nature,425, 846.Thayer, S.P., et al. 2003. Nature,425, 851.Watkins, D.N., et al. 2003. Nature422, 313.Cooper, M.K., et al. 1998. Science280, 1603.Kim, S.K. and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA95, 13036.

Packaging

Packaged under inert gas

25 mg in Plastic ampoule

Preparation Note

Slight warming may be required to achieve complete solubilization.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)